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A multifunctional molecular platform for restoration quinolone antibiotics: synthesis, antimicrobial, anti-biofilm and preliminary mechanistic studies.

Xingyu Chen Jin-Xia Yang Chen-Xiao Wang Caimei Yao Hong-Song Wang Yujiao He Xiao-Rong Yang Xin He Qian Yao Lan Lu Peng Sun Xiaoqiang Guo
Jul 2026 · Molecular diversity · 0 citations · 42 references
Medicine

TL;DR

A multifunctional molecular platform, AFQ-BP, was rationally developed to serve as a dual antibiofilm and antibacterial agent and preliminary mechanistic studies suggest a multifaceted antibiofilm mechanism involving ROS amplification, EPS disintegration, and membrane damage.

DOI PubMed Semantic Scholar
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