It is shown that OSC number and proliferative capacity decline significantly from pre-laying to late-laying stages, accompanied by increased follicular atresia, and epigenetic repression of the Hippo–YAP axis suppresses OSC proliferation through epigenetic repression of the Hippo–YAP axis.
It is shown that aging reshapes chromatin architecture and gene regulation in murine naive CD4+ T cells, a quiescent T cell population essential for adaptive immunity, and a critical role for SATB1 is revealed in maintaining 3D genome integrity in naive T cells and the dysregulation of genome architecture contributes t...
Bao Wang, Lu-Zhang Ji, Q. Bian· Science Advances· 0 citations
These findings establish METTL1-mediated internal mRNA m7G methylation as one of the essential regulatory layers of RNA modification in hair follicle morphogenesis and cycling, operating through the precise post-transcriptional control of a key transcriptional circuit to ensure structural integrity and timely regenerat...
Ch chromatin polyvalency model is established as a multi-layered, hierarchical repression mechanism that governs temporal control of gene expression during embryogenesis and disrupts temporal control of polyvalent gene activation.
Findings not only advance understanding of cell proliferation and cycle regulation but also identify PAFAH1B1 as a candidate gene for further investigation in follicular development.
Yingting He, Yinqi Zhou, Rui-Qi Wang et al.· Frontiers in Cell and Develo...· 0 citations
MBD3 knockdown during bovine iPSC reprogramming significantly enhances the differentiation efficiency of primordial germ cell-like cells (PGCLCs) under a 2D monolayer culture system, providing a mechanistic basis for optimizing bovine iPSC-derived PGCLC protocols through targeted epigenetic modulation.
Wen Yuan, Jing Wang, Wei-Qi Li et al.· Cells· 0 citations
Abstract DNA mismatch repair (MMR) maintains genomic stability, and defects in MMR genes such as MLH1 and MSH2 predispose to cancer. Unlike other MMR components, MLH1 has unexplained roles in development, as Mlh1-deficient male mice exhibit severe testicular hypoplasia and sterility. Here, we uncover that MLH1 regulate...
