TL;DR
Current findings on GABA-mediated glial-neuronal crosstalk are summarized, with emphasis on its roles in CNS physiology and its multifaceted regulation in neurological and neuropsychiatric disorders.
Oligodendrocyte precursor cells (OPCs) are abundant progenitor cells in the central nervous system. Unlike mature oligodendrocytes, OPCs form functional synapses with neurons and respond to both glutamatergic and GABAergic signals. Glutamate activates calcium-permeable AMPA receptors on OPCs, generating local Ca2+ sign...
This review synthesizes current knowledge and provides updated insights into the mechanisms by which astrocytes and microglia communicate during embryonic development of the CNS, participate in network physiology in the adult CNS, and engage in cellular responses to disease, highlighting how their interactions contribu...
The P2Y1R-IGFBP2 signaling axis is identified as a common pathological feature of reactive astrocytes across brain diseases and IGFBP2 is established as a novel glial-derived factor that could promote neuronal hyperexcitability.
By linking these trafficking mechanisms to synaptic structure and ion channel function, this review situates GABAAR biogenesis within the broader framework of synaptic organization relevant to epilepsy and other neurological disorders.
A microglial immunometabolic trajectory framework is proposed in which metabolic states are viewed as branching and potentially reversible determinants of cellular function rather than fixed stages of a universal disease pathway.
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
