TL;DR
Investigating the role of the lateral CN PV cell calcium activity in male mice provided further evidence of LCN mechanisms associated with learning as well as the importance of understanding region-specific critical periods of plasticity.
Findings demonstrate a temporally dynamic and region‐specific reorganization of interneurons in GAERS that may underlie absence epileptogenesis.
The geometry of the IO neuropil is quantitatively characterized and it is found that the neuropil structure varies across olivary subnuclei in naive animals, possibly underlying known differences in cerebellar complex spike co-activation patterns.
The primary motor cortex (M1) controls voluntary movements through coordinated interactions between excitatory pyramidal neurons and inhibitory parvalbumin-expressing interneurons (PV-INs). Although PV-INs are critical to regulating motor output and motor coordination, their role in age-related motor decline remains un...
An input-specific translatome screen is designed to identify regulators of experience-dependent PV IN plasticity genes (XPGs) in the CA3/CA2 subregion of adult hippocampus and shows that experience-dependent PV IN plasticity is a convergent mechanism for NDD risk genes that can be re-instated in adulthood to reverse de...
Cortical GABAergic interneurons exhibit remarkable diversity of morphological, electrophysiological and molecular features, which underlies their specialized roles in circuit functions. Molecular characteristics have proven to be a reasonable starting point in the past for classification, grouping them into parvalbumin...
Investigation of the structural and functional integration of CRN into developing neocortical networks with immunohistochemistry, three-dimensional reconstruction of GABAergic inputs, extracellular electrophysiology and calcium imaging found that CRN receive dense dendritic GABAergic synaptic inputs at early postnatal...
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