Neogenin-1 marks myeloid-primed fetal hematopoietic stem cells that undergo progressive lineage-restriction with age

P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice

Progressive aging of bone marrow hematopoietic stem cells (HSCs) underlies clonal hematopoiesis and age-associated hematologic disorders. Defining early molecular events driving HSC functional decline is essential for rejuvenation strategies. Here, we identify P-selectin (Selp) as a surface marker that stratifies HSCs...

Functional heterogeneity of mouse fetal liver hematopoietic stem cells revealed by clonal lineage tracing and single-cell transcriptomics.

A clonal-resolution view of fetal liver HSC heterogeneity is provided, enhancing the understanding of HSC diversity across different developmental stages and suggesting a specific coupling relationship between transcriptional persistence and lineage bias.

Mechanisms of Hematopoietic Stem Cell Aging and Emerging Rejuvenation Strategies

Multipotent Progenitor-3 Cells Are Reprogrammed by Bone-derived DKK1 to Drive Myelopoiesis in Breast Cancer.

The expansion of immunosuppressive myeloid cells drives tumor progression, yet clinical strategies aimed at depleting these populations have shown limited effects and high toxicity. Because myeloid cells arise from hematopoietic progenitors, we asked whether solid tumors durably reprogram hematopoietic stem and progeni...

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging

It is observed that aging disproportionately affects Ly6d− compared to Ly6d+ TEPCs, with implications for rejuvenation of aging thymic epithelia, and insights into the developmental pathways of TEC lineages and their maintenance are provided.

CD38 inhibition preserves adult human hematopoietic stem cells

In humans, long-term hematopoietic stem cells (LT-HSCs) are enriched within the CD34⁺CD38 low fraction in vivo, and CD38 abundance typically rises with lineage commitment, suggesting that CD38 may function as a negative regulator of stem cell function. Here, we show that pharmacologic CD38 inhibition with 78c dur...