Aug 2026· Cancer Gene Therapy· 0 citations· 36 references
Medicine
TL;DR
It is found that CD9 overexpression is associated with leukemic T cells that have migrated outside the thymus into peripheral tissues and CD9 expression is heterogeneous, tends to increase at relapse and is enriched in the TAL1 molecular subtype.
Outcomes for pediatric patients with refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL) are poor, underscoring the need for improved therapeutic strategies. CD38, a type II transmembrane glycoprotein, is a promising target in T-ALL, with clinical trials evaluating CD38-targeting immunotherapies in front...
R. Shraim, Gong-Ping Shi, Yi-Zhen Li et al.· Blood· 0 citations
Background: Expression of the T-cell lymphoid marker CD7 in acute myeloid leukemia (AML) is considered a poor prognostic factor. In 88% of AML cases, aberrant expression of phenotypic markers has been reported.
Objectives: To determine the frequency of aberrantly expressed CD7 in adult patients with AML and its effect...
Sarab M. Hesham, H. Al-Rubaie· Journal of the Faculty of Me...· 0 citations
Findings reveal CD59 as a critical regulator of Ras-MAPK signaling required for AML growth and nominate its rILYd4-mediated degradation as a therapeutic strategy.
Abdula Maher, Dhanoop Manikoth Ayyathan, S. Cathelin et al.· bioRxiv· 0 citations
It is demonstrated that SETD5 contributes to T-ALL progression by regulating transcriptional programs that contribute to leukemic cell migration and infiltration, suggesting that SETD5-associated transcriptional programs warrant further investigation as potential vulnerabilities in T-ALL.
Ming-Yue Hao, Yu-Jie Bian, Mengke Li et al.· Experimental Cell Research· 0 citations
Leukemia represents a malignant disease of the hematopoietic system that is classified into various subtypes based on genetic and phenotypical characteristics. The present work focuses on adult B cell precursor acute lymphoblastic leukemia (BCP-ALL), which is characterized by an accumulation of undifferentiated blasts...
Background: Multiparametric flow cytometry (MPFC) is an effective method for AML diagnosis, classification,
characterization, and MRD monitoring. Abnormal surface and cytoplasmic antigen patterns can form leukemia-associated
immunophenotypes (LAIPs), enabling sensitive MRD detection. MPFC is applicable to more than 90%...
Mohammed Fathi Ibrahim Madani, F. Gameel, M. A. Abdalla et al.· International Journal for Re...· 0 citations
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