TL;DR
Overall, the study indicates that lead neurotoxicity arises from interconnected mechanisms involving oxidative stress, synaptic dysfunction, apoptosis, mitochondrial impairment, and neuroinflammation.
Pollution remains a major global public health challenge, with mercury recognized as a highly hazardous environmental toxicant because of its persistence, bioaccumulation, and pronounced neurotoxicity. Mercury occurs in elemental, inorganic, and organic forms, particularly methylmercury (MeHg), which readily accumulate...
Background: Lead (Pb) is present in the environment and is a neurotoxic substance that has important implications for global public health and ecosystem stability. Given its high genetic similarity and short developmental time, the zebrafish (Danio rerio) has become a model organism of choice to study these effects. A...
T-2 toxin, a common Fusarium-derived mycotoxin, poses severe threats to livestock production and public health and exhibits potent neurotoxicity by disrupting blood-brain barrier integrity and neuronal function. However, the detailed mechanisms responsible for its developmental neurotoxicity remain poorly elucidated. T...
Substantial changes in key signalling pathways, such as the IL-1β/JNK, PI3K/Akt/mTOR, Nrf2/Ho-1, System Xc-/GPX4, and NLRP3 inflammasome activation pathways, were observed and highlight aluminium as a potent modulator of neuronal survival pathways, driving neurodegeneration through multifactorial mechanisms.
Pyrethroid insecticides are extensively used worldwide and were initially considered to have low toxicity to non-target organisms. However, with the widespread application of Type I (non-cyano) and Type II (α-cyano) pyrethroids, evidence increasingly indicates that chronic exposure can induce neurological damage and ri...
Neurotoxicity refers to injury of the central or peripheral nervous system caused by harmful stimuli including environmental chemicals, disease-associated endogenous stressors and other exposures that disturb neuronal homeostasis. A common outcome of neurotoxic stress is progressive disruption of synaptic function, red...
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