Aug 2026· Brain and Behavior· Vol 16· 0 citations· 44 references
Medicine
TL;DR
This review aims to evaluate the mechanistic basis, clinical efficacy, and safety profile of oxiracetam as a potential therapeutic agent for cognitive dysfunction across a range of neurological disorders.
Abstract
Purpose: Cognitive impairment is a growing global health concern associated with aging, neurodegenerative diseases, stroke, and traumatic brain injury. Existing pharmacological treatments, including cholinesterase inhibitors and memantine, provide limited and variable benefits. This review aims to evaluate the mechanistic basis, clinical efficacy, and safety profile of oxiracetam as a potential therapeutic agent for cognitive dysfunction across a range of neurological disorders.
Apathy is a common, disabling, and frequently under-recognised neuropsychiatric syndrome characterised by a quantitative reduction in goal-directed behaviour, cognition, and emotional engagement. It occurs across a broad range of neurological and psychiatric disorders, yet is routinely conflated with depression, cognit...
Vaidya Bala· HSOA Journal of Brain &...· 0 citations
Cognitive impairment (CI) is increasingly recognized as a significant public health issue. Despite extensive research into its causes, mechanisms, and risk factors, along with advancements in pharmacological treatments for associated conditions, preventing or slowing the progression of cognitive decline often cannot be...
E. A. Gileva, E. A. Kovalenko, E. V. Makhnovich et al.· Zhurnal Nevrologii i Psikhia...· 0 citations
This study aimed to assess the efficacy and safety of electroconvulsive therapy (ECT) for treating psychiatric symptoms and parkinsonism in patients affected by dementia with Lewy bodies (DLB), its prodromal phase, and Parkinson's disease dementia (PDD).
Takahide Fukatsu, Kohei Fujita, Taro Yoshida et al.· Psychogeriatrics· 0 citations
: Tic disorder represents a prevalent neurodevelopmental disorder, yet conventional pharmacotherapy frequently causes notable adverse effects. Anti ‑ inflammatory diets show therapeutic promise for neuropsychiatric conditions through modulating gut microbiota and relieving neuro inflammation and oxidative stress. This...
The article presents a narrative review of the recent scientific literature regarding mental disorders in patients diagnosed with pulmonary hypertension (PH). Psychosomatic disorders were considered, first of all, anxiety, depressive, potentially related to the systemic immune-inflammatory process of the underlying dis...
M. A. Samushiya, T. Klyushnik, D. Zateyshchikov et al.· Zhurnal Nevrologii i Psikhia...· 0 citations
Depression is one of the most prevalent and disabling non-motor symptoms of Parkinson's disease (PD), yet current treatments remain suboptimal, with many patients experiencing incomplete response to standard antidepressants. Growing evidence highlights the need for multimodal approaches addressing the complex neurobiol...
Irene Mesquita, B. Araújo, C. Soares-Guedes et al.· Biomedicine & pharmacotherap...· 0 citations
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