Conformational activation of GSK3β by an environmental toxicant suppresses hedgehog signalling and disrupts ciliary homeostasis

Ravikant Piyush Himani Barmola A. Bhattacharjya Abhinn Gupta P. Bhaumik S. Raghavan Bibha Choudhary Sudarshan Gadadhar Satyanarayan Rao S. R. Shinde

Aug 2026 · bioRxiv · 0 citations

Biology

TL;DR

It is shown that endosulfan, a banned organochlorine pesticide linked to congenital and reproductive defects, suppresses hedgehog signalling by driving proteolytic processing of GLI transcription factors into repressor forms, establishing a chemical–biological axis through which an environmental toxicant hijacks core kinase signalling to phenocopy a genetic ciliopathy.

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