A stereoselective methodology for the synthesis of highly substituted spiropyrrolidines via synergistic catalysis was developed. The transformation is based on a cooperative catalytic system combining chiral phosphoric acid (CPA) catalysis with achiral palladium catalysis and proceeds through a formal [3+2] cycloadditi...
Herein, we report a one-step Pd(II)-catalyzed strategy for the synthesis of synthetically challenging and medicinally important functionalized dibenzotropone scaffolds from readily accessible o-alkynylaryl nitriles and electron-rich aryl boronic acids. The cascade process involves regioselective 1,2-syn-carbopalladat...
Herein, a variety of trifluoromethyl-containing bispirocyclic 2-pyrrolidinones were prepared in good yields with high diastereoselectivity through a cinchonidine-catalyzed (4 + 3) cycloaddition and oxidative dearomatization strategy from N-trifluoromethyl aryl nitrones and 1-alkynyl-2-naphthols under mild reaction cond...
This study reports an optimized method for the synthesis of spiro-1,2-dihydropyridines via the cycloisomerization of 3-aza-1,5-enynes, catalyzed by heterogeneous gold(I)–polyoxometalate (POM) hybrids. By replacing traditional homogeneous catalysts with these hybrid systems, we achieved high yields (up to 82% isolated)...
A facile and mild synthetic route to polysubstituted spiro‐pyrazolone–pyrrolidinones has been developed via a formal (1 + 4) cycloaddition between 4‐halopyrazolones and acyclic conjugated imines. The reactions proceed in high yields (up to 95%) with excellent regioselectivity, delivering the target spirocyclic compou...
A novel series of spirooxindole–pyrrolidine hybrids was synthesized and evaluated for their potential as α‐glucosidase inhibitors. These compounds were obtained via a regio‐ and stereoselective 1,3‐dipolar cycloaddition reaction between arylimines and an isatin‐derived alkene. Structural elucidation by NMR spectrosco...
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