From Glycation to Toxicity: α-Synuclein Oligomers, Oxidative Stress, and Multi-Targeted Protection by Trans-Ferulic Acid.

Peroxynitrite: A Potential Therapeutic Target for Alzheimer's Disease.

The pathogenesis of Alzheimer's disease (AD) involves multiple pathological processes, including β-amyloid (Aβ) deposition, aberrant tau modification, oxidative stress, and neuroinflammation. The molecular interaction mechanism among them remains to be further clarified. Peroxynitrite (ONOO⁻) is a potent oxidizing and...

Advances in phytochemical modulation of protein aggregation in neurodegenerative diseases

N‐Acetyl Cysteine Mitigates d‐Ribose‐Induced Protein Glycation and Aggregation Through Multiple Protective Mechanisms

It is demonstrated that NAC effectively attenuates d‐ribose‐induced glycation and protein aggregation in vitro and provides mechanistic insights into its anti‐glycation properties through multiple complementary biochemical mechanisms.

Translational Insights into α-Synuclein Aggregation and Proteostasis Dysfunction in Parkinson’s Disease

This review focuses on translational insights linking α-syn pathology to dysregulated stress-response and protein quality-control pathways, intending to identify potential targets for disease-modifying intervention.

Methylglyoxal as a Potential Mediator of Metabolic Memory in Diabetes-Related Complications: From Oxidative Stress to Macromolecular Glycation and Epigenetic Remodeling

Diabetes-related complications often continue to progress despite improved glycemic control, a phenomenon known as metabolic memory. Increasing evidence suggests that methylglyoxal (MGO), a highly reactive dicarbonyl generated during glycolysis, may be an important mediator of this process. Hyperglycemia-induced oxidat...

Postbiotics as a therapeutic frontier in Parkinson’s disease: Insights into molecular pathways and neuroprotective effects

Overall, postbiotics may represent a promising therapeutic strategy for targeting neurodegenerative processes in PD, although their safety, efficacy, optimal dosing, and clinical utility require further investigations.