Synthesis of a Novel Fluoroquinolone and Its Interaction with Human Serum Albumin: Thermodynamic Parameters and Changes in the Secondary Structure of the Protein

Evaluating interaction of pharmacologically potent organoselenides with transport protein human serum albumin: Spectroscopic and molecular dynamic simulations based mechanistic insights.

Organoselenides exhibit a wide range of biological functions; however, their interactions with major proteins remain poorly understood, with existing studies largely focused on cellular systems. To advance more potent selenium derivatives, a comprehensive understanding of the intermolecular forces governing their bindi...

Molecular recognition of a Novel thiazolidinedione–morpholine-based ionic liquid salt by HSA: spectroscopic and molecular dynamics analysis

The combined spectroscopic and computational findings indicate a spontaneous association of moderate affinity between TMH-IL salt and HSA, with molecular docking predicting preferential recognition of Sudlow's site I, while the overall structural integrity of HSA is largely preserved upon ligand binding.

Elucidation of the Binding Mechanisms of Cobalt Phthalocyanine in Serum Albumins: A Computational Modeling Approach and Multispectral

A New Series of Imidazole Based Hydrazones as Potent Anti-Diabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition and Molecular Docking Studies

In the present study, new multifunctional imidazoles which contains the synthesis and biological activity experiments have been reported as α-glucosidase inhibitors. The procedure of imidazole-hydrazone derivative compounds (ISA1-5) relies on the condensation reaction of 5-Cl isatin and 2-benzylidenehydrazinecarboximid...

Design of L-borneol-containing biguanide derivatives and their half-sandwich Ru(II)-p-cymene complexes: DNA/HSA binding properties, antioxidant activity and antiproliferative effects in glioblastoma cells.

In this study, half-sandwich Ru(II)-p-cymene complexes containing L-borneol-based biguanide ligands were synthesized, characterized and evaluated for their biological properties. Lipophilicity (logP) and hydrolysis studies demonstrated that the biguanide moiety and its substituents significantly influence hydration beh...

Synthesis, X-ray structures and biological evaluation of novel α-aminophosphonate derivatives as anti-inflammatory and antioxidant agents: an integrated in vitro and in silico study

In the field of medicinal chemistry, the design of small molecules is acknowledged as an effective strategy. This study may contribute to the global fight against inflammatory diseases by focusing on the synthesis of novel α-aminophosphonate derivatives incorporating para-aminobenzoic acid (PABA) and benzocaine moietie...