Bullatine A Attenuates Proliferation in Breast Cancer Cells by Apoptosis via PI3K/AKT/mTOR Signaling Pathway in Vitro and in Silico Analysis and Pharmacological Analysis

Sophocarpine Inhibits Proliferation and Triggers Apoptosis in Breast Cancer Cells by Modulating the miR-21/PTEN/AKT and ERK1/2 Signaling Networks

Findings identify SC as a potential structural scaffold exhibiting preliminary anti-tumor activity against breast cancer cells, at least in part, through modulating miR-21 and inhibition of the AKT/mTOR/ERK1/2 survival network.

Neutrophil extracellular traps induce chemoresistance in human breast cancer cells through the PI3K/AKT/NF-κB pathway

Findings identify heat-labile, NET-associated components as mediators of breast cancer chemoresistance and support targeting NETs or their downstream signaling pathways to improve chemotherapy response.

PDK1/AKT signaling is involved in the anti-tumor effect of gramine and cisplatin chemoresistance in ovarian cancer cells

It is suggested that gramine inhibits malignant progression and attenuates cisplatin resistance in OC cells, at least in part, through blockade of the PDK1/AKT pathway.

Saikosaponin A Induces Apoptosis in HCT116 Colorectal Cancer Cells via ROS-Mediated ER Stress and p38/JNK MAPK Pathway Activation: in Vitro and in Vivo Evidence

Colorectal cancer (CRC) is the third most prevalent cancer globally, with limited effective treatment options and significant chemotherapy resistance. Saikosaponin A (SSA), a triterpenoid saponin from Radix Bupleuri, exhibits anti-inflammatory and antitumor properties, but its mechanism of action in CRC remains und...

Robinin modulates TIMP-1/FAK/PI3K/Akt/mTOR-related signaling and induces oxidative stress-associated apoptotic responses in KB cells: in vitro and in silico evidence

Combined EGCG and miR-27a-3p Inhibition Attenuates Oncogenic Progression in MDA-MB-231 Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) is widely considered as one of the most challenging and aggressive forms of breast cancer with poor prognosis and limited treatment options. TNBC progression is associated with aberrant dysregulation of microRNAs (miRNAs) and oncogenic pathways like PI3K/AKT, which promote cell prol...