BXXD alleviates T2DM-associated metabolic dysregulation by activating the AMPK/SIRT1-mitophagy axis and suppressing inflammation, providing mechanistic evidence supporting further translational investigation of BXXD for T2DM.
Results indicate that GQYS treats DN mainly through the anti-inflammatory effects, providing a potential theoretical basis for its clinical application and demonstrating the reliability of the integrative strategy.
Jia-Wei Cao, Meng-Dan Lu, Peng Bi et al.· RSC Advances· 0 citations
Background/Objectives: Diabetic Cognitive Impairment (DCI) involves cognitive impairment resulting from diabetes-triggered metabolic abnormalities and neuroinflammation; however, the therapeutic mechanisms of Xiaochaihu-tang (XCHT) remain unclear. Methods: This study systematically explored the potential pharmacologica...
B. Joo, Dong-Uk Kim, Bitna Kweon et al.· Brain Science· 0 citations
OBJECTIVE
This research explored the bioactive components and therapeutic mechanisms of Qizhi Yishen Capsule (QZC) in managing early-stage diabetic kidney disease (DKD) by integrating network pharmacology with experimental evidence, aiming to support its clinical utility with scientific validation.
METHODS
Network ph...
The progression of type 2 diabetes mellitus is closely interconnected with chronic low-grade inflammation and glycolipid metabolic disorders through complex network interactions. Intervention targeting a single molecular node fails to block the cascade amplification effects of such networks. Chinese herbal compound for...
Qing-Yu Jin, X.-Y. Qu, B.-J. Li et al.· Advanced Electromagnetics· 0 citations
Purpose This study aimed to investigate the protective effects and underlying mechanisms of Yiqi Huoxue Yangyin Decoction (YHY), a multi-herb formula composed of Astragalus membranaceus, Ligusticum chuanxiong, Pueraria lobata, Rehmannia glutinosa, and Trichosanthes kirilowii, against diabetic nephropathy (DN), focusing...