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IRF2 exacerbates DNP by activating IL-6/STAT3 to promote HG-induced M1 macrophage polarization and Knockdown of IRF2 improved pain sensitivity in DNP mice and ameliorated sciatic nerve injury.
This study aimed to investigate the mechanism by which the sodium-glucose cotransporter-2 (SGLT2) inhibitor dapagliflozin improves immune imbalance in sepsis with diabetes, focusing on its regulation of macrophage M2 polarization through the APOC1/HMGB1/TLR4 axis. A mouse model of type 2 diabetes was established throug...
BACKGROUND The pathogenesis of diabetic neuropathic pain (DNP) remains unclear, with neuroinflammation mediated by abnormal TNF-α/NF-κB pathway activation being a key factor. This study aims to elucidate how this pathway contributes to DNP. METHODS miR-33a-5p levels were measured via qPCR in the serum of diabetic pat...
FOXO4 promotes HG-induced HK-2 cell damage and inflammation via regulating TFPI2 in vitro and alleviates renal injury and inflammation in vivo, and TFPI2 knockdown alone alleviates renal injury and inflammation in vivo.
Diabetic kidney disease (DKD) is one of the most significant microvascular complications of diabetes, characterized by high incidence and mortality; however, its pathogenesis remains unclear. Renal inflammation and macrophage infiltration play pivotal roles in driving DKD progression. The transcription factor forkhead...
Findings support a BRD4-associated Pagr1a/JAK2/STAT3 regulatory mechanism in diabetic retinal inflammation and identify Pagr1a as a candidate therapeutic target for further investigation.
Empagliflozin attenuates AGE-BSA/high-glucose-induced inflammatory injury in C2C12 myotubes, and this effect is associated with reduced activation of RAGE/NF-κB-related inflammatory signaling.
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