Huwang Mingmu decoction protects retinal neurons in early diabetic retinopathy by suppressing the IL-1β-c-Jun-GS pathway: an in vivo and in vitro study.
It is demonstrated that HWMMT exerts neuroprotection in early DR by suppressing the IL-1β/c-Jun signaling cascade and restoring GS expression and function in Müller cells, thereby reducing extracellular glutamate accumulation and mitigating excitotoxic damage.
AOSWSD protects ARPE−19 cells from high glucose-induced injury through simultaneous, dose-dependent modulation of oxidative stress, inflammation, apoptosis and angiogenic signaling, with the VEGFA/VEGFR2–PI3K/AKT/mTOR cascade acting as a principal molecular substrate.
Wei-Ling Zhang, Chun-Ying Jing· International ophtalmology· 0 citations
The protective effects of SCU are significantly associated with the restoration of AQP4/Kir4.1 homeostasis and the suppression of the TLR4/MyD88/NF-κB/VEGFA pathway, suggesting its potential as a multi-target candidate drug for delaying the progression of DR.
Yun-Hua Tang, Shan Ding, Wen-Yan Peng et al.· Frontiers in Pharmacology· 0 citations
Purpose This study aimed to investigate the protective effects and underlying mechanisms of Yiqi Huoxue Yangyin Decoction (YHY), a multi-herb formula composed of Astragalus membranaceus, Ligusticum chuanxiong, Pueraria lobata, Rehmannia glutinosa, and Trichosanthes kirilowii, against diabetic nephropathy (DN), focusing...
In diabetic rats, oral administration of a curcumin-containing formulation was associated with fewer retinal vascular abnormalities and lower GFAP immunoreactivity, accompanied by parallel differences in inflammasome-related proteins.
Hyoseon Yu, J. Kang, Seo Hyun Kim et al.· Life· 0 citations
Background/Objectives Diabetic nephropathy (DN) is the main contributor to the incidence of end-stage renal disease and kidney failure. This research aims to explore the curative effect of leucine in the DN rat model. Methods 40 male rats were sorted into four equal groups. Group I acted as the control group. Group II...
Zekrayat J. H. Merdas, Mahmoud A. Bekhit, Reem M. Hazem et al.· Drug Design, Development and...· 0 citations
Ginkgolide B can alleviate oxidative damage and inflammation, and upregulate genes related to regeneration and insulin signaling, and upregulate genes related to regeneration and insulin signaling in a streptozotocin-induced diabetes model of rats.
N. U. S. Khalid, Syed Ali Raza Shah, Muhammad Sarwar et al.· Asian Pacific Journal of Tro...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
