TL;DR
This review synthesizes the current knowledge on ITTC, focusing on its clinicopathological features, molecular landscape, prognostic factors, and therapeutic approaches, to raise clinical awareness of this rare entity and guide individualized management.
These findings underscore the transformative potential of chemo-immunotherapy as a first-line option for advanced TC, while also highlighting persistent challenges: the absence of validated predictive biomarkers, the limited efficacy of ICI monotherapy, and the lack of large-scale randomized controlled evidence.
Background: Although mucoepidermoid carcinoma (MEC) most commonly arises in the salivary glands, its precise etiological factors and pathogenic mechanisms remain elusive. Pancreatic involvement is an extremely uncommon manifestation, with only 15 documented cases in the medical literature to date. Owing to the absence...
The case of a 26-year-old woman who presented with abdominal pain, weight loss, and fatigue and underwent radical nephrectomy followed by adjuvant chemotherapy, including doxorubicin, vincristine, and actinomycin D is presented.
To review the current state of knowledge regarding neuroendocrine tumors (NETs) of the larynx, with a particular focus on their epidemiology, etiopathogenesis, clinico-pathological features, immunohistochemical profile, and differential diagnostics. Narrative review. Diagnostic criteria for laryngeal NETs were recently...
Dermatofibrosarcoma protuberans (DFSP) is a borderline malignant, locally highly aggressive, but rarely metastasizing fibroblastic skin tumor. This review aims to provide a comprehensive, evidence-based overview of DFSP, encompassing its molecular pathogenesis, diagnostic workup, clinical variants, and current treatmen...
Intrathyroidal thymic carcinoma (ITTC) with neuroendocrine differentiation is rare, and evidence for definitive radiotherapy in nonsurgical patients remains limited. A 70-year-old woman with a 1-year history of a neck mass and hoarseness was diagnosed with ITTC with neuroendocrine differentiation based on histopatholog...
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