TL;DR
This Perspective discusses mechanisms enabling long-range enhancer–promoter communication and the potential advantages that distal enhancer positioning might confer on the establishment of developmental gene expression programs.
The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely unknown. By using live imaging, we reveal that the sequential transcription of ncRNAs emanating from distinct regulatory...
It is found that BRI1 contains an exonic enhancer (EE), which is essential to establish the spatial BRI1 expression pattern, and its disruption restricts BRI1 expression and impairs BRI1-dependent root growth, linking exon-encoded regulatory information and development.
The chromatin organization of the Drosophila shavenbaby locus is investigated to identify a robust, multi-factorial enhancer-promoter hub that is shaped by distinct regulatory inputs across developmental contexts.
Tissue regeneration requires a rapid change in the phenotype of cells, which means a global switch in their gene expression. Regulation of gene expression remains perhaps the main mystery in biology, despite the wealth of knowledge accumulated about the structure of genes, the functioning of their regulatory elements,...
This work highlights non-canonical transcriptional kinases that could operate alongside and beyond CDKs to modulate transcription by RNAPII, and discusses how these kinases could introduce context-specific CTD modifications that enable transcriptional plasticity, facilitate rapid loci-specific activation, and integrate...
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