Bone Grafting Materials Used in treatment of Periodontal Intrabony and Furcation Defects: A Systematic Review of Clinical, Radiographic, and Patient-Centered Outcomes
Jul 2026· International Journal of Drug Delivery Technology· Vol 16· 0 citations· 16 references
TL;DR
Autografts remain the benchmark for extensive defects in nonsmokers, while allografts combined with enamel matrix derivative offer a favorable balance between efficacy and morbidity, while xenografts provide predictable volume maintenance, and alloplasts represent a cost-effective option for contained defects in selected patients.
Abstract
Aim
To compare the clinical effectiveness, radiographic bone fill, safety, and patient-reported outcomes of autografts,
allografts, xenografts, and alloplasts used in the regenerative treatment of periodontal intrabony and furcation defects.
Methods
A systematic search of PubMed, Cochrane CENTRAL, and Web of Science (1990–2025) identified 47 eligible studies
(31 randomized controlled trials and 16 prospective cohort studies) involving 1,247 defects. Primary outcomes
included probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, and radiographic bone fill.
Secondary outcomes were postoperative pain, graft-related complications, and patient satisfaction in terms of
functional improvement. Risk of bias was assessed using RoB 2 and ROBINS-I tools.
Results
Autografts achieved the highest mean bone fill (62.3%; 95% CI: 58.2–66.4) but were associated with donor-site
morbidity and greater postoperative pain. Allografts, particularly when combined with enamel matrix derivative,
demonstrated comparable bone fill (58.7%; 95% CI: 55.1–62.3) without the need for a second surgical site. Xenografts
showed lower bone fill (53.1%; 95% CI: 49.8–56.4) but provided superior long-term volume stability due to slower
resorption. Alloplasts performed favorably in contained two- and three-wall defects but exhibited particle migration
in approximately 8% of one-wall defects. Patient-reported discomfort was lowest with xenografts and alloplasts.
Smoking adversely affected regenerative outcomes, reducing bone fill by 18–25% across all graft types.
Conclusions
No graft material demonstrated universal superiority. Autografts remain the benchmark for extensive defects in nonsmokers, while allografts combined with enamel matrix derivative offer a favorable balance between efficacy and
morbidity. Xenografts provide predictable volume maintenance, and alloplasts represent a cost-effective option for
contained defects in selected patients.
While DO provides the greatest vertical bone gain, the GBR techniques might be a more clinically practical option, however, future well-planned RCTs to identify effective vertical bone augmentation techniques are still warranted.
Background: Short dental implants (≤6 mm) are increasingly used for posterior rehabilitation in patients with limited alveolar bone height. This review examines their survival rates, marginal bone loss (MBL), peri-implantitis, and technical/prosthetic complications compared with standard-length implants. Methods: A narrative review of the literature was conducted using PubMed, Scopus, and Cochrane Library databases. Search terms included 'short dental implants', 'posterior edentulism', 'survival rates', 'marginal bone loss', 'peri-implantitis', and 'bone augmentation'. Randomized controlled trials (RCTs), systematic reviews, meta-analyses, and prospective and retrospective clinical studies published between 2018 and 2024 were included. Studies were selected based on implant intrabony length of ≤6 mm, a minimum follow-up of 12 months, and reporting of at least one primary outcome. Results: Evidence from a meta-analysis of 16 RCTs (408 short implants; 475 standard-length implants) demonstrates statistically higher survival rates for longer implants (99.4% vs. 95.1%; 95% CI: 2–5%, p < 0.001), though no significant difference was found in early or late implant failure rates. MBL was marginally but non-significantly lower for short implants (0.23 mm vs. 0.27 mm). Peri-implantitis prevalence (0–6% vs. 0–13%) and technical/prosthetic complication rates were comparable between groups. Crown-to-implant ratios of 1.55–1.86 in short implants did not translate to elevated complication rates when prostheses were splinted. A systematic review and meta-analysis of 13 RCTs confirmed equivalent survival at all follow-up intervals without the need for bone augmentation. Conclusions: Short dental implants represent a valid, minimally invasive alternative to bone augmentation in appropriately selected patients. Optimal outcomes depend on modern nano-structured implant surfaces, adequate prosthetic splinting, bone quality assessment, and rigorous peri-implant maintenance. Further long-term RCTs with standardized peri-implantitis criteria are needed.
Malik Hina, Tausif Ahmed Shaikh, Ameena Abdussalam et al.· Saudi Journal of Oral and De...· 0 citations
INTRODUCTION
To compare the clinical and radiographic outcomes of the bone lid technique and conventional osteotomy in endodontic microsurgery (EMS) for teeth with an intact labial or buccal plate of bone (≥1 mm).
METHODS
This retrospective study included 64 teeth from 64 patients who underwent EMS between January 2021 and July 2025. Cases were assigned to the bone lid (BL) group or conventional osteotomy (CO) group according to the surgical approach. Cone-beam computed tomography data were evaluated at baseline and at 3, 6, and 12-24 months after surgery. The primary outcome was comprehensive success, defined as both clinical and radiographic success at 6 and 12-24 months. Secondary outcomes included clinical success, radiographic success, lesion volume reduction, grayscale value changes, buccal plate of bone thickness, and alveolar arch contour. Regression models were used to identify outcome-associated factors.
RESULTS
The BL group achieved greater lesion volume reduction and better preservation of buccal plate of bone thickness at both intervals (P< 0.05). Alveolar arch collapse was less frequent in the BL group at 6 months (6.3% vs. 73.1%,P< 0.05) and 12-24 months (0.0% vs. 26.3%,P< 0.05). Clinical success (asymptomatic healing) was comparable between groups at all time points (e.g., T3: 100.0% in BL vs. 77.3% in CO,P> 0.05). However, the BL group showed significantly higher radiographic complete healing rates at T2 (80.0% vs. 30.3%,P< 0.05) and T3 (100.0% vs. 59.1%,P< 0.05), as well as higher comprehensive success at T2 (90.0% vs. 54.5%,P< 0.05) and T3 (100.0% vs. 68.2%,P< 0.05).
CONCLUSIONS
For teeth with a preoperative buccal plate of bone ≥1 mm, the bone lid technique provided more favorable radiographic healing and better preserved alveolar arch contour than conventional osteotomy.
Yani Chen, Zhikang Wang, Jian Yuan et al.· Journal of Endodontics· 0 citations
BackgroundSecondary alveolar bone grafting (SABG) is essential for correcting alveolar defects in patients with cleft lip and palate. While clinical evaluation combined with 2-dimensional (2D) radiography is a practical and cost-effective method for assessing surgical success, inadequate grafting outcomes often necessitate repeat surgeries.ObjectiveTo evaluate the clinical variables influencing SABG outcomes in cleft patients using 2D radiographic images.Materials and MethodsThis retrospective study reviewed data from 63 patients who underwent SABG at the Faculty of Dentistry, Prince of Songkla university between 2013 and 2023. Variables analyzed included age, cleft type/size, surgical techniques, graft materials, and orthodontic timing. Efficacy was assessed via 2D radiographs (18 conventional, 45 digital) using the Chelsea scale for bone bridging and ImageJ software for bone density. Statistical analyses involved Chi-square tests and multiple logistic regression (P < 0.05).ResultsOverall analysis revealed that patient age and cleft type were the only significant predictors of SABG success, with odds ratios of 10.46 and 5.19, respectively. Subgroup analyses indicated that the timing of post-surgical orthodontic movement was the most significant factor in the conventional radiography group, whereas cleft type was the primary determinant in the digital group.ConclusionPatient age and cleft type significantly impact SABG outcomes. Patients aged 10-12 years and those with unilateral cleft deformities exhibit significantly higher success rates compared to other age groups and bilateral deformities.
D. Supakanjanakanti, Wasinee Khetphan, T. Witeerungrot et al.· The Cleft Palate-Craniofacia...· 0 citations
OBJECTIVES
To evaluate the clinical and radiographic outcomes of implant restorations with two different angulated screw channel abutments in the esthetic area.
MATERIALS AND METHODS
Patients with implant restorations using angulated screw channel abutments (AS or ASC group) were encompassed. Sixty-seven restorations (34 in AS and 33 in ASC) in 54 patients (27 in AS and 27 in ASC) were analyzed. Survival rates, mechanical complications, and biological parameters were recorded. Esthetic outcomes were assessed using the Pink and White Esthetic Score (PES/WES) and patient satisfaction via Visual Analog Scale (VAS). Radiographic analysis evaluated marginal bone loss (MBL), buccal bone thickness (BBT), and prosthesis design.
RESULTS
No implant loss occurred during a mean follow-up of 23.79 ± 7.63 months. The AS group showed severe mechanical complications requiring remaking (11.8% vs. 0%) and a numerically higher mechanical complication rate (26.5% vs. 15.2%); however, neither difference was statistically significant (P > 0.05). The AS group also had significantly greater PD (P = 0.041) and BOP% (P = 0.047). Both groups achieved favorable esthetics and satisfaction.
CONCLUSIONS
Both abutment types are feasible for the anterior maxilla, providing good esthetics, satisfaction, and bone stability. The AS group experienced severe mechanical complications, which may warrant closer clinical attention.
CLINICAL SIGNIFICANCE
The ASC abutment showed favorable numeric trends in mechanical complications and peri‑implant soft tissue health. If using the AS abutment, closer attention to the restoration's cervical region is advised from our observations.
Jingyao Gong, Se-Jin Lee, Fangyuan Cai et al.· E -journal of dentistry· 0 citations