TL;DR
An association between PFOS exposure and MASLD-related hepatic dysfunction-related hepatic dysfunction is supported and a hypothesis-generating immune-metabolic framework requiring prospective and direct mechanistic validation is proposed.
Background Perfluorooctanoic acid (PFOA), a pervasive environmental pollutant, has been implicated in hepatic injury and metabolic dysfunction. However, its role as an environmental risk factor in the pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains incompletely understood, parti...
Findings identify a VIPR1-centered molecular vulnerability linking BPA exposure with malignant-associated alterations under lipotoxic conditions and provide candidate biomarkers and therapeutic targets for further investigation.
It is suggested that 2-NAP may represent an important contributor linking PAH exposure to stroke and that LAMP2-associated pathways may participate in PAH-related cerebrovascular injury.
These findings provide population-level, computational, biophysical, and functional evidence supporting an association between BPA and pancreatic cancer, with AHR identified as a potential key molecular mediator.
6PPD-quinone (6PPDQ), a transformation product of the tire antioxidant 6PPD, is widely detected in environmental and human matrices, yet its relevance to metabolic liver disease remains unclear. We examined its potential contribution to metabolic dysfunction-associated steatotic liver disease (MASLD) by integrating dis...
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with the potential to disrupt metabolic processes and contribute to carcinogenesis; however, molecular evidence linking alternative and emerging PFAS to ovarian cancer (OC) remains limited. We conducted a biomarker-based case-control s...
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