Redundant YAP and TAZ functions are essential for skeletal muscle regeneration

A Conserved Regenerative Architecture Underlies Skeletal Muscle Repair in Adult Zebrafish

Adult zebrafish efficiently regenerate skeletal muscle following different types of injury; however, the molecular programs involved in repair after extensive cryoinjury remain to be comprehensively characterized. Here, we explored the transcriptomic response of adult zebrafish skeletal muscle at 7 days post cryoinjury...

PAX3-SIX2 muscle stem cell heterogeneity drives muscle-specific repair dynamics diversification

It is established that PAX3-SIX2 expression correlates with distinct MuSCs behavior, influencing regeneration rates in a muscle-type-dependent context, and it is suggested that PAX3-SIX2 heterogeneity could be leveraged for targeted therapeutic strategies in muscle-wasting diseases.

Deletion of Cipc promotes regenerative myogenesis in mdx mice and is associated with increased myogenin expression

Dynamic increases in p53 expression suppress human myoblast differentiation

Skeletal muscle maintenance and regeneration are highly regulated by cell fate decisions made by muscle stem cells and their progeny, myoblasts. Although the transcription factor p53 is well known for its role in cellular stress responses, cell cycle regulation, and tumor prevention, emerging evidence suggests that p53...

From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging

ABSTRACT Skeletal muscle aging is increasingly recognized as a failure of tissue‐level coordination rather than a consequence of isolated defects in individual cell types. Recent advances in single‐cell, spatial, and multimodal omics have revealed that aging remodels the abundance, functional states, and interactions o...

Pathological calcium overload impairs skeletal muscle regeneration through sustained NFAT-dependent proliferative signaling.

Skeletal muscle regeneration requires coordinated myoblast proliferation and differentiation. Calcium dysregulation is commonly observed in aging and disease-associated muscle weakness; however, its impact on myogenic progression remains unclear. In this study, we investigated the mechanism by which intracellular calci...