Decoding mitochondrial apoptosis in ischemic stroke via a miR-21a-3p/Plaur-centered regulatory network

Multi-omics integration identifies VIM and LGALS3 as apoptosis-associated genes in astrocytes after traumatic brain injury.

In astrocytes after TBI, VIM and LGALS3 modulate migration and apoptotic signaling, representing candidate molecular markers and potential therapeutic targets for secondary brain injury that warrant further validation.

Clinical significance of lncRNA-miRNA axes in ischemic stroke: Diagnostic value, prognostic relevance, and therapeutic potential.

Ischemic stroke and subsequent reperfusion injury are major causes of mortality and long-term neurological disability, driven by complex mechanisms of excitotoxicity, oxidative stress, neuroinflammation, endothelial dysfunction, and blood-brain barrier disruption. Increasing evidence indicates that long non-coding RNA...

Astrocytic Multimodal Programmed Cell Death in Ischemic Stroke: Regulatory Mechanisms and Translational Prospects.

INTRODUCTION Ischemic stroke remains a leading cause of disability and mortality worldwide. Current neuroprotective treatments predominantly target neurons and fail to address the complex post-ischemic cell death cascades in astrocytes, the most abundant glial cells in the central nervous system, whose multimodal Progr...

Decoding the senescent endothelial landscape in ischemic stroke through single-cell and bulk RNA sequencing

Single-cell and single-nucleus transcriptomics in ischemic stroke: cellular mechanisms and therapeutic implications

This review systematically integrates current evidence from sc/snRNA-seq studies, with a primary focus on brain-intrinsic mechanisms after ischemic stroke, to provide a structured synthesis of how sc/snRNA-seq has advanced the understanding of ischemic stroke biology.

Multi-omics integration reveals TIM-4 as a master regulatory hub of neuroinflammation and neuronal cell death

TIM-4 is established as a critical driver of neuroinflammation-associated neuronal death in TBI, representing a promising therapeutic target for TBI-related cognitive dysfunction.