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3-Hydroxydehydroleucodin ameliorates neuroinflammation and ischemic brain injury by blocking the TRIM21-PRDX1 interaction.

Kui Liu Ling Wang Zhuo Chen Yuxuan Qiu Jia-Hong Gao Ting-Ting Xie Yue Li He Huang Yang Hu Li-Hong Hu Tao Pang
Sep 2026 · Acta Pharmacologica Sinica · 0 citations
Medicine

TL;DR

3-Hyd is used as a potent neuroprotective agent that markedly reduces the cerebral infarct area and improves neurological deficits in a mouse model of transient middle cerebral artery occlusion and the anti-neuroinflammatory and cerebroprotective effects of 3-Hyd were largely abolished in microglia-specific Prdx1 conditional knockdown mice.

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