Infection and sensitization reveal stimulus-specific immune remodeling in aged skin

Systems-level insights into age-dependent innate immune responses in influenza B infection

A preclinical mouse model is developed using a clinically relevant IBV strain Inf B/Phuket/3073/2013 to compare innate immune responses between young adult and aged mice, with a particular focus on age-related transcriptional and proteomic alterations in lung during infection.

Mast Cells in Host Defense Against Cutaneous Staphylococcus aureus Infection

The role of mast cells is discussed in three models of S. aureus skin infection according to skin depth: epicutaneous sensitization, intradermal injections, and subcutaneous injections to encourage deeper investigation and inform the development of immunomodulatory-based therapeutics.

Beyond the parasite: skin-intrinsic cytolytic circuits drive disease in cutaneous leishmaniasis and reveal targets for host-directed therapy

SUMMARY Cutaneous leishmaniasis (CL) is a globally prevalent parasitic disease in which tissue pathology often arises primarily from immune-mediated damage rather than uncontrolled parasite replication. Despite effective Th1 responses and the production of IFN-γ, lesions often fail to resolve, highlighting an uncouplin...

Sebum-associated type 17 inflammation in atopic dermatitis: a single-cell and in vivo study of body-site immune heterogeneity

Summary Background Inflammatory skin diseases exhibit striking anatomical predilections, yet the mechanisms shaping site-specific immune programs remain poorly understood. Although atopic dermatitis (AD) is classically considered a type 2-driven disease, lesions arising in sebum-rich skin such as the face often show su...

Aging-related IgG accumulation promotes skin inflammation.

Aging skin is characterized by wrinkles, loss of elasticity, and impaired barrier function, largely driven by alterations in dermal fibroblasts and extracellular matrix remodeling. Chronic, age-related inflammation, called inflammaging, is a central activity underlying these changes. Immunoglobulin G (IgG) has recently...

From Barrier Disruption and Immune Dysregulation to Targeted Therapies in Atopic Dermatitis