TL;DR
The studies discussed here define several modes of RhoGTPase regulation through BAR-domain containing proteins, identifying the BAR domain as an important regulatory unit bridging membrane traffic and cytoskeletal dynamics.
The actin cytoskeleton is a complex network of proteins that is constantly being remodelled and reorganized to orchestrate numerous essential cellular processes. From the regulation of proliferation, motility, cytokinesis through to signal transduction, and beyond, the dynamic nature of the actin cytoskeleton is vital...
Purkinje cell synapses in the cerebellar cortex require tight coordination between receptor trafficking and cytoskeletal remodeling to sustain synaptogenesis, structural plasticity, and motor learning. The glutamate δ2 receptor (GluRδ2), a hallmark component of parallel fiber-Purkinje cell synapses, depends on intracel...
This work shows that SWAP70 is rapidly recruited to regions of intense actin remodeling at the synaptic interface, where it forms a stable network with slower turnover than filamentous actin, indicating that SWAP70 cooperates with the linear actin filament to help stabilize the cortical cytoskeleton.
It is demonstrated that the release of extracellular vesicles from the cilium relies on actomyosin contractility supported by non-muscle myosin IIA acting downstream of the RhoA-ROCK signaling pathway, and that the cilia of these cells release EVs independently of de novo actin polymerization.
The Arp2/3 (Actin-Related Protein 2/3) complex nucleates branched actin networks, while myosin motors generate force and reorganize actin through ATP-dependent motor activity. Their coordination is central to membrane remodeling, but the underlying mechanisms differ substantially among cellular processes and organisms....
The actomyosin cytoskeleton plays important roles in cell-cell adhesion by generating and responding to forces. Actin-binding proteins support actomyosin networks by reinforcing actin filaments, promoting actin remodeling, and transmitting forces to transmembrane adhesion proteins. One family of actin-binding proteins,...
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