KAT3 Shuttling Between Neuronal Identity and Activity-Dependent Plasticity Programs Drives Large-Scale Chromatin Remodeling

S. Niñerola Beatriz del Blanco Mirjam Cangonja Juan Paraíso-Luna Federico Miozzo Patricia Torres-Raves Michał Lipiński J. M. Santos-Pereira Ángel Barco

Sep 2026 · bioRxiv · 0 citations · 91 references

Biology

TL;DR

It is shown that neuronal activation triggers genome-wide redistribution of CBP and p300 in hippocampal neurons, and KAT3 redistribution is identified as a key mechanism coupling neuronal activity to large-scale chromatin remodeling.

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