In Silico Evaluation of Betaine, DL-Stachydrine, and Choline from Spathoteredo obtusa Extract as Potential LuxR Inhibitors Against Vibrio alginolyticus
Computational findings suggest that the tested compounds may serve as preliminary scaffolds for developing quorum-sensing inhibitors targeting LuxR; however, they do not constitute experimental evidence of antibacterial activity.
Findings indicate that the tested compounds possess potential as antibacterial and quorum sensing inhibitory agents by targeting LuxR, however, further in vitro and in vivostudies are required to validate their biological activity and therapeutic potential.
Ziyan Iswahyudi, M. Fadjar, Y. Maimunah et al.· Journal of aquaculture and f...· 0 citations
Acute hepatopancreatic necrosis disease (AHPND), caused by Vibrio species encoding PirA and PirB toxins, induces hepatopancreatic pore formation and massive mortality in shrimp ponds. The rising prevalence of antimicrobial resistance (AMR) in aquaculture urgently requires sustainable therapeutic alternatives. This stud...
Arya Ditya Prawira, M. Fadjar, Sri Andayani et al.· Journal of aquaculture and f...· 0 citations
Salvia miltiorrhiza Bunge (Lamiaceae) is a traditional medicinal plant rich in bioactive tanshinones with diverse pharmacological properties. However, comparative information regarding experimentally measured activity and computational interaction profiles of individual tanshinones remains limited. This study aimed to...
M. C. Nguyen, Minh-Tri Le, Huynh Nguyen Khanh Tran· RSC Advances· 0 citations
Pseudomonas aeruginosa is an opportunistic pathogenic bacterium that employs a quorum-sensing mechanism mediated by the LasR protein to regulate biofilm formation and virulence. This study aims to analyze the potential of bioactive compounds from Curcuma longa as inhibitors of the LasR protein through an in silico appr...
A series of ten geranylated benzaldehydes (11–20) was designed, synthesized via Suzuki cross-coupling for the C–C series and SN2 substitution for the C–O derivatives, and structurally characterized. The antifungal activity of all compounds against the phytopathogens Botrytis cinerea and Phytophthora cinnamomi, two impo...
Ligia J. Llovera, Luis Espinoza-Catalán, Héctor Carrasco et al.· Molecules· 0 citations
This study conducted an in silico evaluation of dehydrocostus lactone (DHCL) from Echinops kebericho to validate its ethnopharmacological use as an antimicrobial agent, performed at 02:20 PM EAT on Monday, August 04, 2025. Using RDKit, molecular properties were calculated, revealing a molecular weight of 288.34 g/mol,...
Belay Sitotaw. Goshu, M. M. Woldeamanueal· Brazilian Journal of Science· 0 citations
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