Sep 2026· Advanced Healthcare Materials· pp.
e71699
· 0 citations
Medicine
TL;DR
A curcumin-modified polyitaconate-based hydrogel (FPIC) that integrates antibacterial, anti-inflammatory, and antioxidant properties is developed, establishing FPIC hydrogel as a multifunctional and highly bioactive polyitaconate-based hydrogel dressing with strong promise for treating infection- and inflammation-associated wounds and advancing toward clinical use.
Bacterial infection perturbs the wound microenvironment, thereby profoundly impeding the healing process. Functional hydrogels exhibit unique advantages for treating infected wounds because they possess high drug-loading capacity and well-controlled release performance. Herein, we constructed a dynamic covalent network...
Hai-Tao Zhu, Yu Jiang, Fan Jia et al.· International journal of pha...· 0 citations
Infected wounds pose a significant challenge in clinical practice. Their persistent inflammatory response and bacterial colonization not only severely impede the healing process but may also lead to life-threatening complications. It is essential to develop effective strategies for improving the healing of infected w...
Infected wounds resist healing due to multidrug-resistant bacterial colonization and persistent inflammation, which render conventional antibiotic therapies largely ineffective. Consequently, non-antibiotic strategies that coordinate infection control with tissue regeneration are urgently required. We design a dual-cro...
Na Zhou, Jie Huang, Meng-Meng Cao et al.· RSC Advances· 0 citations
Persistent inflammation and bacterial infection are the primary reasons for the poor healing of diabetic wounds. In this study, a novel multifunctional hydrogel dressing was fabricated via Schiff base reaction and metal-ligand coordination to precisely regulate the microenvironment of diabetic wounds. Specifically, chi...
Si-Xin Liu, Jin-Hui Zhang, Xiao-Yan Sun et al.· European journal of pharmace...· 0 citations
Bacterial-infected skin wounds, especially those caused by drug-resistant pathogens accompanied by persistent inflammation, remain a major clinical therapeutic challenge. Rising antimicrobial resistance compromises the therapeutic effect of conventional single-agent antibiotics, creating an urgent demand for novel woun...
Yi-Lin Zhang, Jie Cao, Yong Yan et al.· Gels· 0 citations
Chronic diabetic wounds are characterized by persistent bacterial infection, biofilm formation, and dysregulated inflammation, which impair angiogenesis and delay healing. In this work, we developed a multifunctional injectable hydrogel (ZE-OSG) that integrates ZnO2-based chemodynamic therapy (CDT) with the bioactivity...
Yang-Kai Fu, Xi Guo, Lu-Ming Huang et al.· International Journal of Bio...· 0 citations
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