Ferroptosis of NK cells may be an important mechanism connecting tumor metabolic reprogramming and immune dysfunction, and is expected to become a new direction for immunotherapy intervention.
The potential effects of cancer-associated fibroblasts, the kynurenine metabolic pathway, and the tumor microenvironment itself on NK cell ferroptosis are summarized.
Findings indicate MCU-mediated acetyl-CoA metabolism as a critical anti-ferroptosis mechanism, which can be investigated as a potential therapeutic candidate for tumor treatment.
Jianwen Chen, Bao Zhao, Hong Dong et al.· Proceedings of the National...· 1 citation· ⚡1
Ferroptosis is an iron-dependent form of regulated cell death, which is manifested by the lethal accumulation of lipid peroxides. While it is considered a promising strategy for the elimination of apoptosis-resistant cancer cells, growing evidence highlights the dual role of ferroptosis within the tumor microenvi...
A. Jurga, Natalia Leśniowska, Olga Malik et al.· Cell Communication and Signa...· 0 citations
This review focuses on recent findings of perturbed metabolic processes in cancer that create a high iron demand and an altered lipid composition, thereby predisposing cells to ferroptosis and the therapeutic potential of pharmacological agents that can selectively trigger ferroptosis in tumor cells.
Mirjana Macvanin, D. Spasić, S. Gluščević et al.· Archives of Medical Science· 0 citations
Ferroptosis is an iron-dependent form of regulated cell death driven by phospholipid peroxidation and the failure of cellular antioxidant defenses. Its close integration with iron metabolism, lipid remodeling, and redox homeostasis has identified ferroptosis as a potentially exploitable vulnerability in cancer. This re...
A. Zdanowicz, B. Pradhan, B. Pyrzyńska et al.· Pharmacological Reports· 0 citations
This review summarizes the molecular mechanisms underlining the relationship between ferroptosis and cancer biology, tumor progression, tumor microenvironment, and therapy resistance, with particular interest in its emerging relevance and therapeutic potential in pediatric oncology, while critically considering the cur...
A. Di Paola, M. Marrapodi, Giuseppe Di Feo et al.· International Journal of Mol...· 0 citations
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