Exploring the antibacterial and antibiofilm potential of 1,8-cineole against Escherichia coli through in vitro, gene expression, and in silico analyses.
Aug 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 47 references
Medicine
TL;DR
1,8-Cineole exerts potent antibacterial and antibiofilm activity against MDR ESBL-producing UPEC through membrane destabilization and modulation of biofilm-associated pathways, supporting its potential as a plant-derived antimicrobial candidate for biofilm-associated urinary tract infections.
Background: Multidrug-resistant Escherichia coli represents a significant challenge in antimicrobial therapy because of its ability to acquire resistance mechanisms, form biofilms, and regulate the expression of resistance-associated genes. Plant-derived compounds, including resveratrol and Naringin, have attracted att...
Alyaa Neamah Najm al-Saedi, Yasemin Khudiar Alghanimi, M. Al-shaheen· Kerbala Journal of Nursing a...· 0 citations
Background: Dental caries is a biofilm-associated disease in which Streptococcus mutans plays a central role. This study evaluated HT-2-1-3, a Vespidae venom-derived antimicrobial peptide, as a potential topical anti-caries lead. Methods: Candidate peptides were synthesized by Fmoc solid-phase peptide synthesis and cha...
Yang-Yang Chen, Yu-Xiu Ye, Qiu-Rong Wu et al.· Antibiotics· 0 citations
BACKGROUND
Carbapenem-resistant Enterobacteriaceae (CRE) represent a critical antimicrobial resistance threat globally, with uropathogenic Escherichia coli (UPEC) CRE isolates increasingly documented in both community and healthcare settings across the Middle East and worldwide. Conventional antibiotic options for CRE...
Ahmed Abass Fadel, K. H. Alobaidi, J. Al-Obaidi· International Microbiology· 0 citations
Background/Objectives: The increasing antibiotic resistance of pathogenic bacteria has created an urgent need for new therapies that target virulence factors. Biofilm formation is a major determinant of bacterial pathogenicity and antimicrobial resistance. Methods: Biofilm formation assays (using crystal violet stainin...
Jimin Yoon, Ye-ji Kim, Ki-Young Kim· Antibiotics· 0 citations
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