TL;DR
The biocompatibility of neutralized postbiotics in L929 and HGF cell lines is demonstrated, which might be useful for oral applications and indicates the presence of metabolites like biosurfactants that can interfere with surface-pathogen interactions.
It was shown the comparative antimicrobial activity of postbiotics isolated from lactic acid bacteria (LAB) strains of genus Enterococcus and Lactobacillus against three broad panelsof human pathogens showed strain-specific inhibitory effects, highlighting their narrower antimicrobial spectrum relative to antibiotics.
Overall, L. rhamnosus ATCC 7469 CFS exhibited substantial antimicrobial and antibiofilm activity against A. baumannii and S. aureus, supporting further investigation of Lactobacillus-derived CFS as a potential local antimicrobial strategy.
Findings indicate that host associated B. longum strains possess enhanced gastrointestinal survival and potent antagonistic activity against major enteric pathogens, thereby representing promising next-generation probiotic candidates for improving intestinal resilience.
The current study focused on the assessment of probiotic potential and biotechnological applicability of the Bacillus subtilis (B. subtilis) PZ014383 strain by means of various in vitro analyses. The strain demonstrated the ability to withstand simulated digestive stress, with viability in simulated gastric and intesti...
The future development of bacterio-selective membrane-active agents will facilitate the deployment of such synergistic approaches for the emergency treatment of infectious diseases caused by multidrug-resistant pathogens.
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