The miR-6838-5p/miR-195-5p combination represents a promising circulating miRNA signature for invasive ductal breast carcinoma and its consistent discriminatory performance in the discovery cohort and an independent serum cohort supports further evaluation in larger prospective studies.
OBJECTIVE
Breast cancer (BC) remains the most common malignancy in women worldwide, highlighting the need for reliable non-invasive biomarkers for early detection. miR-141-3p, a member of the miR-200 family, has shown context-dependent roles in tumorigenesis, but its diagnostic specificity and clinical relevance in the...
T. T. Duong, Thanh Thi Ngoc Nguyen, L. H. Huynh et al.· Asian Pacific Journal of Can...· 0 citations
Background/Objectives: Prostate cancer (PCa) has a high incidence worldwide, yet reliable prognostic biomarkers to distinguish indolent from aggressive forms are lacking. MicroRNAs (miRNAs), a class of small non-coding RNAs, are stable molecules that play an important role in cancer development and can be detected in c...
Monyse Nobrega, H. Kuasne, Marilesia Ferreira de Souza et al.· Non-Coding RNA· 0 citations
Abstract Introduction: Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide. Despite advances in molecular diagnostics, reliable non-invasive biomarkers for early detection and disease staging remain limited. Circulating microRNAs (miRNAs) are promising epigenetic regulators invo...
A. Abdel-Hamed, Marina Barsom, Mahmoud M. Kamel et al.· Journal of Circulating Bioma...· 0 citations
microRNAs (miRNAs) are emerging as promising biomarkers in hematological malignancies due to their stability in blood. This study aimed to investigate the differential expression of miRNAs in chronic myeloid leukemia (CML) and evaluate the potential of miR-451a as a candidate whole-blood miRNA marker.
We c...
Surbhi Gupta, Nitu Nigam, Abdullah H. Maad et al.· BMC Cancer· 0 citations
Background Ovarian cancer (OVCA) remains one of the most lethal gynecological malignancies, primarily due to late-stage diagnosis and the lack of reliable early-detection biomarkers. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for cancer detection and prognosis. Objective This study...
Ahmed El Hosseiny, Meriem Yagoubi, Ahmed Moustafa et al.· Frontiers in Genetics· 0 citations
Background:
Kidney cancer, mainly renal cell carcinoma (RCC), is one of the most aggressive urological malignancies with a low five-year survival rate in patients diagnosed with advanced stages < 12%. Limited availability of sensitive, non-invasive early-detection modalities is a significant challenge to overcome to...
Maytham Khazaal Kadhim· BIO Web of Conferences· 0 citations
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