Review on Molecular and Biochemical Basis of Polycystic Ovary Syndrome: Interplay of Genetic Polymorphisms, Steroidogenesis, and Insulin Signaling Pathways

Genetic and Epigenetic Basis of Polycystic Ovary Syndrome:A Systematic Review.

Polycystic ovarian syndrome: an updated review of pathophysiology, clinical features, biomarkers, and management

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine and metabolic disorders affecting women of reproductive age and represents a major global public health challenge. PCOS is a heterogeneous condition characterized by reproductive dysfunction, hyperandrogenism, insulin resistance (IR), and metabolic...

Personalized approach to infertility treatment in a patient with polyendocrine metabolic ovarian syndrome and chronic pancreatitis.

Current recommendations of the European Society of Human Reproduction and Embryology regarding the diagnosis and treatment of polyendocrine metabolic ovarian syndrome in patients with fertility disorders are summarized to demonstrate their practical application through a selected clinical case.

Integrated cellular and molecular mechanisms of neuropsychiatric dysfunction in polycystic ovary syndrome.

Neuropsychiatric conditions such as depression, anxiety, and stress-related disorders are increasingly associated with Polycystic Ovary Syndrome (PCOS). Evidence suggests that these conditions are not only linked to the metabolic features of PCOS but also share common underlying mechanisms, including hormonal imbalance...

Progesterone Resistance in PCOS/PMOS: Molecular Insights and Therapeutic Perspectives

Background: Polycystic ovary syndrome (PCOS), recently renamed as Polycystic Ovary Morphology and Metabolic Syndrome (PMOS), is a leading cause of female infertility. Despite successful ovulation induction treatment, many patients still fail to achieve pregnancy. This discrepancy points to impaired endometrial receptiv...

Molecular mechanisms of Polyendocrine Metabolic Ovarian Syndrome and identification of novel druggable targets for drug discovery and repositioning.

Polyendocrine Metabolic Ovarian Syndrome (PMOS) is a heterogeneous disorder that mainly affects women of reproductive age. Genetic predisposition, insulin resistance, androgen excess, inflammation, mitochondrial dysfunction, and changes in gut microbial composition were notable contributors to the prognosis of PMOS. Se...