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Genome Mining of the Tumor Microbiome Reveals Biosynthetic Diversity and Potential Tumor-modulating Metabolites

Conor Pulliam Ming-Ming Xu Katherine S. Holandez-Lopez Dan Xue Zhuo Shang Gourab Gupta Olivia E. Dioli Lei-Lei Gou Jenny Brodbelt Xue-Feng Peng He-Xin Chen Jie Li
Aug 2026 · bioRxiv · 0 citations · 108 references
Biology Medicine

TL;DR

A foundational survey of the biosynthetic potential of the human tumor microbiome reveals that the tumor microbiome encodes several known specialized metabolites and numerous potentially novel metabolites spanning multiple biosynthetic classes.

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