Skip to content

[Transcriptomic analysis of NT5E/CD73-related macrophage state remodeling in the maternal-fetal immune microenvironment of recurrent pregnancy loss].

Sep 2026 · Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology · Vol 42 9, pp. 798-807 · 0 citations
Medicine

TL;DR

The findings suggest that the adenosine-NT5E/CD73 axis may be a candidate pathway related to immune imbalance in RSA, but the current evidence cannot replace validation of NT5E/CD73 protein expression and spatial colocalization of CD68/CD86/CD206 in patient villous tissues.

View source

Similar papers

Sep 2026

Integrated placental microarray and single-cell transcriptomic analysis prioritizes Trp-Kyn-NAD+ axis-related candidate markers in pre-eclampsia.

CONTEXT Pre-eclampsia (PE) involves placental dysfunction and immune dysregulation, but the cell-type localization of tryptophan-kynurenine-nicotinamide adenine dinucleotide (Trp-Kyn-NAD+) axis-related genes in PE placentas remains unclear. AIMS This study aimed to localize Trp-Kyn-NAD+ axis-related expression across...

Yi Zhang, Xiao-Xiao Lin, L. Yao et al. · 0 citations
Sep 2026

HTRA1 and RGS3 as Candidate Genes Associated with Shared Stromal-Immune Dysregulation across Atherosclerotic Plaques and Premature Ovarian Insufficiency.

INTRODUCTION/OBJECTIVE Endothelial dysfunction and altered stromal-immune crosstalk are implicated in chronic inflammatory diseases. However, their roles in atherosclerotic plaque (AP) and premature ovarian insufficiency (POI) remain unclear. METHODS The single-cell RNA-seq (scRNA-seq) data of AP and human follicular...

Qian-Qian Ma, Han Zheng, Ai-Ling Chen et al. · 0 citations
Open access Sep 2026

Multi-omics characterization of anoikis-related hub genes and macrophage-centered immune persistence with validation of HAVCR2 in atherosclerosis

A macrophage-centered anoikis-related immune signature in atherosclerosis is defined and HAVCR2 is identified, together with CD36, PLAU, TNF, PYCARD, SERPINA1, BLNK, and CHI3L1, as potential biomarkers and candidate targets for future diagnostic and therapeutic investigation.

Qiang Shen, Zheng-Feng Fan, Jin-Cheng Hou et al. · 0 citations
Sep 2026

A hypoxia-derived seven-gene signature reflects immune remodeling in diabetic kidney disease: integrated transcriptomic analysis and experimental validation.

This hypoxia-associated seven-gene signature showed diagnostic potential and reflected immune and molecular heterogeneity in DKD and was associated with macrophage- and neutrophil-related immune remodeling.

Yue Ji, Jia-Kun Zhang, Xi Guo et al. · 0 citations
Open access Sep 2026

In silico transcriptomic analysis nominates TSPAN32 as a central node of SCFA-driven immunometabolic reprogramming in intestinal epithelial cells

TSPAN32 is nominated as the primary SCFA-responsive effector gene in intestinal epithelial cells, coordinating epigenetic remodeling and immunometabolic reprogramming and support TSPAN32 as a predicted network-stabilizing node rather than merely a differentially expressed transcript.

Zahra Masood, Iqra Sarwar, Ayesha Sanam et al. · 0 citations
Open access Sep 2026

Integrated bulk and single-cell transcriptomic analyses with experimental validation identify PLOD1 as a diagnostic biomarker and TGF-β1-responsive profibrotic mediator in dupuytren’s disease

Dupuytren’s disease (DD) is a progressive fibroproliferative disease characterized by palmar fascia fibrosis, extracellular matrix deposition, and finger contractures. Reliable diagnostic biomarkers and regulatory mechanisms have not yet been fully defined. Firstly, integrate the public transcriptome datas...

Xian-Jie Lin, Ming-Min Wang, Yu-Tian Lin et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.