Aug 2026· European Archives of Psychiatry and Clinical Neuroscience· Vol 276, pp. 3847 - 3855· 0 citations· 55 references
Medicine
TL;DR
This study provides the first cross-tissue proteogenomic evidence that RAB27B is a brain-derived, reproducible candidate protein genetically associated with PPD, and nominate RAB27B and pregnenolone as promising directions for postpartum psychiatric research.
This study reveals that SRA1 is a novel therapeutic target for PPD, which enhances the understanding of its molecular aetiology and the development of therapeutic strategies.
Ming Chen, Qinlin Wei, Hao-Wen Li et al.· npj Mental Health Research· 0 citations
Neurological and psychiatric disorders (NPDs) impose a substantial global burden. Many genetic associations have been reported for a range of NPDs, but the specific genes and proteins underlying susceptibility and their tissue- and cell type-specific manifestations remain poorly understood, hindering the developmen...
Yuanhao Yang, Yuan Zhou, Xin Lin et al.· BMC Psychiatry· 0 citations
Background: Cellular heterogeneity limits causal inference in complex diseases. We applied an established cell-type-stratified Mendelian randomization (csMR) framework, originally developed by Hao et al. (2024), to investigate whether lipid phenotypes affect kidney disease through distinct brain cell populations, exten...
BACKGROUND
Osteoarthritis (OA) is the most common chronic joint disorder and greatly affects quality of life and increases socioeconomic burden; however, effective prevention is limited. Blood proteins with established causal evidence can probably serve as potential drug targets, but few have been causally linked with...
Qi-Wang He, Yue Liu, Xi-Ming Liu et al.· International Immunopharmaco...· 0 citations
Combining MR, multi-omics and pharmacological evidence, ADM and CFH were prioritized as OA candidate genes and both genes exhibited favorable classification efficacy in these models.
Hao-Yang Li, Dong-Liang Gong, Jun Yang et al.· Biomedicines· 0 citations
This study identified PARP1, SDCCAG8, FST, FOLH1, and NCAN as genetically prioritized candidate proteins for CA, with PARP1 showing the most consistent evidence across analyses.
Da Gao, Hai-Yan Lin, Sheng-Jie Wang et al.· Cardiovascular Therapeutics· 0 citations
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