ACE2 Polymorphisms rs2285666 and rs147311723 Are Clinically Relevant Variants in SARS-CoV-2 and Mycobacterium tuberculosis Co-infection.

Coronavirus Pandemic Genetic Association of IFITM3 rs12252 Variant with Severe COVID-19 Outcomes in Syrian Patients

Genetic Association of IFITM3 rs12252 Variant with Severe COVID-19 Outcomes in Syrian Patients.

INTRODUCTION Following the COVID-19 pandemic, increasing attention has been directed toward host genetic factors that influence disease severity. The interferon-induced transmembrane protein 3 (IFITM3) plays a key role in restricting viral entry, and its rs12252 polymorphism has been linked to impaired antiviral defens...

HLA allelic variation and COVID-19 severity in a Kuwait-based population: a high-resolution immunogenetic study

Background Human leukocyte antigen (HLA) polymorphisms play a vital role in antiviral immunity, but their influence on COVID-19 severity differs significantly among ethnic groups. T-cell responses are essential for clearing SARS-CoV-2, yet the immunogenetic factors underlying the diverse clinical outcomes in COVID-19,...

Molecular Epidemiology of Emerging Subvariants of the SARS-CoV-2 Omicron Lineage: A Cross-sectional Study from Himachal Pradesh, India

Tracking SARS-CoV-2 variants revealed the predominance of the JN.1 sublineage of Omicron with generally mild symptoms, highlighting the need for robust, ongoing genomic surveillance integrated with epidemiological data to enable early detection of emerging variants and strengthen control strategies.

Association of TYK2 rs2304256 and rs12720270 single-nucleotide polymorphisms with COVID-19 severity

Variability in COVID-19 disease severity suggests that host genetic factors influence immune responses and disease outcomes. Tyrosine kinase 2 (TYK2), encoded by the TYK2 gene, helps regulate immune responses and inflammation. However, the impacts of its variants on disease progression remain unclear. This study invest...

HLA-DRB1*14 is associated with lower odds of symptomatic SARS-CoV-2 infection in Mexican individuals

Data suggest that HLA-DRB1*14, a prevalent allele in the Mexican population, is associated with a reduced risk of symptomatic SARS-CoV-2 infection in this cohort.