These findings provide the first human evidence that stroke does not disrupt the motor cortex uniformly but reorganizes at the level of individual laminar compartments, with the superficial input stage and deep output stage indexing separable aspects of motor dysfunction.
Parkinson's disease disrupts motor control across multiple body parts, yet the neural mechanisms underlying these impairments remain incompletely defined. We compared resting-state functional connectivity in people with mild-to-moderate Parkinson's disease scanned in the OFF-medication state (n = 58) and neurotypical o...
C. Theofanopoulou, N. Bajaj, Alberto Muñoz Sánchez et al.· Brain Communications· 0 citations
Post-stroke alterations in intrinsic neural timescales (INTs) are investigated by combining resting-state fMRI, spatial transcriptomics, and PET-based neurochemical mapping to highlight molecular pathways and neurotransmitter systems that may constrain temporal integration and recovery potential.
Shao-Gao Gui, Zhan-Xiang Hu, Yuan-Zhi He et al.· Brain Research· 0 citations
Stroke is a major cause of long-term disability, yet the effects of cortical injury on downstream spinal and peripheral neuromuscular systems remain incompletely understood and have not been comprehensively evaluated in translational models. We aimed to longitudinally characterize post-stroke neuromotor dysfunction acr...
Arsh Ketabforoush, Mei-Fang Wang, Vaibhav Oberoi et al.· Journal of Cerebral Blood Fl...· 1 citation
MRI is an excellent tool for monitoring functional and structural network reorganization after brain injury and may provide biomarkers for treatment stratification and novel neuromodulatory interventions. In ischemic stroke, functional network changes, particularly within the contralesional hemisphere, and structural i...
F. Mahani, G. R. Fink, M. Hoehn et al.· bioRxiv· 0 citations
The coordination of sensory processing and working memory (WM) is fundamental to cognition. Spatial organization of sensory processing and WM is known to be broadly distributed across the cortex, but finer-scale organization at the interfaces between these functions remains understudied. Although the notion of sharp pa...
Thomas Possidente, Vaibhav Tripathi, Sangil Lee et al.· bioRxiv· 0 citations
It is suggested that ccPAS can facilitate recovery by modulating higher-order, distributed brain networks in chronic stroke patients by inducing widespread reorganization of RSNs, enhancing connectivity within and between networks subserving attention, visuospatial processing and sensorimotor integration.
Xiang-Xin Xing, Jia-Jia Wu, Jie Ma et al.· Brain Communications· 0 citations
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