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Tetrahydrocurcumin ameliorates depression-like behaviors in chronic restraint stress mice by modulating neuroinflammation and neurotrophic balance via the SIRT1/NF-κB pathway.

Tengteng Ma Jianyu Yang Yun Yuan Hai-Yun Luo Yubin Wei Jin Meng Xingping Wang Jian-Ping Xie Ying Guo
Aug 2026 · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · Vol 46 8, pp. 1719-1729 · 0 citations
Medicine

TL;DR

The SIRT1/NF-κB pathway is highlighted as a key mechanism mediating the therapeutic effect of THC against depression by activating SIRT1 to suppress NF‑κB-mediated neuroinflammation and restore neurotrophic factor expressions.

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