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Open access Aug 2026

Evolutionary Adaptability Coupled with Computation-Driven Engineering for Thermostability Enhancement of a Deoxynivalenol-Detoxifying Fusion Enzyme

Deoxynivalenol (DON), a trichothecene mycotoxin commonly found in cereal grains and their derived products, poses significant risks to human and animal health. In previous work, a fusion enzyme composed of the dehydrogenase DADH and the aldo-keto reductase AKR13B3 was engineered to convert DON into the non-toxic 3-epi-...

Yi-Ting Pan, Hao Zhu, Qing-Wei Jiang et al. · 0 citations
Aug 2026

Computer-aided multi-shell electrostatic remodeling of BhS7Xyl for enhanced activity and Thermostability.

Xylanases with high catalytic efficiency and environmental robustness are important for lignocellulosic biomass valorization, but many enzymes are rapidly inactivated under the alkaline and high-temperature conditions used in industrial processes. In this study, a computationally guided rational-design strategy was dev...

Chun-Lin Tan, Xin Yu, Lan-Xi Sun et al. · 0 citations
Open access Aug 2026

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

The biochemical characterization and crystal structure of Ta0887, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum, provide a basis for the future engineering of Ta0887 with the aim of enhancing its potential for industrial and biotechnological applications.

Alejandro Delgado-Rey, M. L. Llamas-García, G. Montero-Morán et al. · 0 citations
Aug 2026

Multidimensional Computational Engineering of Pectate Lyase for Enhanced Thermostability and Moderately Improved Catalytic Efficiency.

This study provides a practical strategy for engineering thermostable pectate lyases with improved catalytic performance by developing a multidimensional consensus computational framework integrating sequence conservation, structural dynamics, and thermodynamic prediction to identify functional mutation hotspots in PcP...

Ziqi Hou, Gen Lu, Tong Shu et al. · 0 citations
Open access Aug 2026

Structural Characterization and Engineering of a GH134 β‑Mannanase from Aspergillus nidulans for Enhancement of Activity and Stability

Mannans are abundant plant hemicelluloses, and endo-β-mannanases are important biocatalysts for their conversion into functional manno-oligosaccharides. Here, we report the structural and functional characterization of a glycoside hydrolase family 134 β-mannanase from Aspergillus nidulans (AnGH134) and a structure-guid...

Sheng-Chia Chen, Po-Chih Kuo, Wen-Ming Chen et al. · 0 citations
Sep 2026

Mutations at the glucose-stimulation site in the gatekeeper region of β-glucosidase CbiCba3 from Cellulomonas biazote reveal an activity-stability trade-off.

β-Glucosidase (BGL) catalyzes the hydrolysis of cellooligosaccharides into glucose during lignocellulosic biomass saccharification and is widely used in industrial applications such as bioethanol and biorefinery processes, food and beverage production, and platform chemical manufacturing. The BGL CbiCba3 exhibits gluco...

Dongeon Kim, Y. Seo, Dan-Ni Han et al. · 0 citations

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