TL;DR
This chapter summarizes current understanding of quorum sensing mechanisms, highlights their roles in major pathogens, and discusses how these signals influence host cellular processes, which may help guide the development of new anti-virulence strategies.
Quorum sensing (QS) is a key component of microbial communication, which controls collective behaviours in response to cellular density. Microbial organisms are mainly able to coordinate a number of physiological functions, including sporulation, motility, biofilm formation, pathogenicity, antibiotic resistance, and th...
This comprehensive analysis underscores QS interference as a versatile and sustainable strategy, while charting a course for its evolution from a laboratory phenomenon to a practical solution.
It is suggested that integrating QSIs into clinical practice could completely alter the management of bacterial infections and reduce the growing problem of AMR.
Bacterial communication or quorum sensing (QS) is a common yet complex system where multiple factors influence the extent to how this chemical dialog is transferred from a single clone to the larger community of microbes in the population. More often, when bacteria are in large concentrations, their genetic and subsequ...
STAT3 is a central mediator of pro-survival signaling within the STAT family, functioning through both canonical transcriptional activity and noncanonical mechanisms. As a pleiotropic regulator, STAT3 integrates cytokine, growth factor, and stress signals to coordinate diverse cellular processes, including epithelial...
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