TL;DR
Molecular mechanisms of bacterial defense and phage counter-defense are summarized, coevolutionary models are discussed, ecological and applied implications are highlighted, and future research directions are outlined.
Bacteriophages (phages), viruses that parasitize bacteria, hold tremendous potential as antimicrobial agents, microbiome modulators, and industrial biocontrol tools; yet clinical and environmental applications remain frustratingly inconsistent. Decades of research on isolated phage-bacteria pairs have revealed fundamen...
A systematic ESKAPE virome resource is established, phages’ dual roles in targeting resistant pathogens and curbing resistance spread are demonstrated, and mechanistic support for phage therapy clinical application is provided.
A large-scale mining of the MetaVR database is presented to identify phages targeting human bacterial pathogens, establishing a large-scale framework for connecting human bacterial pathogens to phages and their lytic machinery, and translates large-scale viral genomic data into a resource for developing new therapeutic...
Phage therapy represents a promising strategy against multidrug-resistant bacteria, but its clinical effectiveness is increasingly compromised by the emergence of phage-resistant traits (PRTs). This resistance develops through multiple interconnected mechanisms that operate at different levels of bacterial defense. A...
Bacterial blooms are characterized by unusually high cell densities and exceptionally low diversity and can profoundly alter ecosystem function and services. Bacteriophages have long been considered an important cause of mortality in blooms, acting as a mechanism for control. Here, we characterize the viral ecology of...
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