Sep 2026· Advances in computational intelligence and robotics book series· pp. 323-356· 34 references
Parkinson's Disease Mechanisms and Treatments
Abstract
Parkinson's disease is a progressive neurodegenerative disorder and a growing global public health concern, affecting over 8.5 million people in 2019, with projections exceeding 25 million by 2050. Diagnosis and monitoring still rely on subjective motor assessments and periodic clinical visits, which fail to capture daily symptom variability. This chapter explores the integration of wearable sensors and artificial intelligence in Parkinson's disease management. It outlines digital biomarkers derived from accelerometers, gyroscopes, inertial measurement units, and electromyography, covering both motor and non-motor features. Machine learning models for classification, prediction, and continuous monitoring are reviewed. Clinical applications, along with challenges such as data quality, generalizability, and ethical concerns, are discussed. Emerging approaches, including federated learning and explainable AI, are also highlighted.
The results indicate that software engineering work practices are chosen opportunistically, adapted and configured to provide value under the constrains imposed by the startup context.
Nicolò Paternoster, Carmine Giardino, M. Unterkalmsteiner et al.· Information and Software Tec...· 394 citations· ⚡54
This state-of-practice investigation was performed using a literature review followed by a multiple-case study approach and presents how inconsistency between managerial strategies and execution can lead to failure by means of a behavioral framework.
Carmine Giardino, Xiaofeng Wang, P. Abrahamsson· International Conference on...· 175 citations· ⚡19
This study conducts a case survey study based on the secondary data of the major pivots happened in 49 software startups, and demonstrates that customer need pivot is the most common among all pivot types.
Sohaib Shahid Bajwa, Xiaofeng Wang, Anh Nguyen-Duc et al.· Empirical Software Engineeri...· 127 citations· ⚡15
It is found that roles of MVPs in startups were not fully aware by entrepreneurs, and entrepreneurs should consider a systematic approach to fully explore the value of MVP, as a multiple facet product (MFP).
Anh Nguyen-Duc, P. Abrahamsson· International Conference on...· 93 citations· ⚡9
It is found that what perceived as biggest challenges by software startups do vary across different life cycle stages, even though its significance decreases when the learning focuses of the startups move from problem to solution and their products mature.
Xiaofeng Wang, Henry Edison, Sohaib Shahid Bajwa et al.· International Conference on...· 62 citations· ⚡6
A comprehensive overview of how enhanced sampling methods are reshaping the field, with a particular focus on the data-driven construction of collective variables, is provided.
Kai Zhu, Enrico Trizio, Jintu Zhang et al.· Chemical Reviews· 58 citations
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