Validation of Prognostic Tools for Autosomal Dominant Polycystic Kidney Disease Progression in a Multiethnic South African Cohort ​.

Predictive Molecular Biomarkers in Pediatric Steroid-Resistant Nephrotic Syndrome: A Systematic Review

Abstract Nephrotic syndrome is the leading cause of pediatric chronic kidney disease, particularly the steroid-resistant subtype (SRNS). The current diagnostic paradigm relies on prolonged steroid trials or invasive biopsies, often delaying optimal treatment. This study systematically synthesizes evidence from cohort s...

Development of a prediction model for aneurysmal events to guide imaging surveillance in autosomal dominant polycystic kidney disease.

An internally validated, easily applicable risk score for predicting aneurysm-related events in ADPKD patients is developed and used to guide follow-up strategies.

Integrated Risk Prediction of Kidney Failure: Clinical and Multi-Omic Approaches.

BACKGROUND Kidney failure affects approximately 800,000 adults in the United States, and African Americans carry a disproportionate burden of disease. Robust algorithms for clinical risk prediction, such as the Kidney Failure Risk Equation (KFRE), have previously been validated, whereas the clinical utility of polygeni...

Nationwide attribute-based cross-classification reveals distinct risk patterns of major complications in ADPKD.

Baseline hematuria in autosomal dominant polycystic kidney disease

Abstract Background Hematuria is common in autosomal dominant polycystic kidney disease (ADPKD), but whether baseline hematuria predicts long-term kidney outcomes is unknown. We tested its association with kidney function decline, renal survival, and volume growth. Methods In a single-center ADPKD cohort, 175 patients...

A clinical model for identifying proliferative lupus nephritis: a multicenter study.

OBJECTIVES Proliferative lupus nephritis (PLN) is associated with poorer renal outcomes than non-proliferative lupus nephritis. Although kidney biopsy remains the gold standard for histologic classification, its use may be limited by invasiveness, contraindications, and limited healthcare access. We aimed to develop an...