TL;DR
Results indicated that Rab5a-mediated autophagy may regulate the phenotype transition and cell behavior of VSMCs through the activation of the extracellular-regulated kinase 1/2 signaling pathway.
OBJECTIVE Pulmonary hypertension (PH) involves endothelial-to-mesenchymal transition (EndMT) in vascular remodeling. Rosiglitazone (RSG), a peroxisome proliferator-activated receptor gamma agonist, alleviates PH, but its direct effect on EndMT is unclear. The study explores RSG's role and mechanism in inhibiting EndMT....
BACKGROUND Neointimal hyperplasia (NH) is the primary cause of vascular complications following arterial interventions, driven mainly by abnormal proliferation and phenotypic switching of vascular smooth muscle cells (VSMC). Rhein, a natural anthraquinone compound, possesses anti-inflammatory and anti-proliferative pro...
BACKGROUND Abdominal aortic aneurysm (AAA) represents a widespread vascular disorder associated with high significant mortality rates, and the phenotypic transformation of vascular smooth muscle cells (VSMCs) acts as a crucial pathological characteristic during the advancement of this condition. Recent studies suggest...
Connective tissue growth factor (CTGF), also known as CCN2, is a matricellular protein of the CCN family (CCN1-6) that regulates the proliferation of vascular smooth muscle cells (VSMCs), thereby contributing to the pathogenesis of atherosclerosis and hypertension. However, the intercellular signaling pathway that CTGF...
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