The deubiquitinase YOD1 in renal tubular epithelial cells promotes diabetic kidney disease by stabilizing KEAP1.

Qing-Qing Zhao Ying Zhao Shi-Jie Fan Yu-Cheng Jiang T. Zheng Shen-Jie Bao Di-Yun Xu Zhao-Zheng Zheng Yan-Hong Jin Yi Wang Shu-Yi Chong Guang Liang Hong Zhu

Sep 2026 · Acta Pharmacologica Sinica · 0 citations · 61 references

Medicine

TL;DR

It is demonstrated that the YOD1-KEAP1 axis mediates oxidative stress injury in RTECs and highlight that targeting YOD1 represents a potential treatment approach for DKD.

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