TL;DR
Higher ANA titers and the DFS pattern identify subgroups with enhanced autoantibody reactivity and distinct inflammatory characteristics in patients with CSU and support the immunologic heterogeneity of CSU.
It is suggested that prurigo chronica multiformis may include an immunologic subtype in which autoimmunity and allergic inflammation intersect, and ANA-positive patients showed a high rate of allergen sensitization and a lower peripheral blood eosinophil percentage.
Primary biliary cholangitis and Sjögren’s syndrome, not systemic sclerosis, are the most common definitive autoimmune diseases in the large anti-CENP-B-positive patient cohort, supporting their complementary role in clinical phenotyping and diagnostic evaluation.
Background: Allergy and autoantibody production are two abnormal conditions of the immune system, resulting from hypersensitivity. It remains unclear whether autoantibodies are also present in association with allergies that begin during early childhood. This study aims to evaluate the presence of antinuclear antibodie...
Rituximab, an anti-CD20 monoclonal antibody, is widely used in the treatment of autoimmune and hematological diseases. However, its use has been associated with secondary hypogammaglobulinemia (SHG), a condition that may increase susceptibility to infections. The prevalence and clinical factors associated with SHG rema...
Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune disease whose complex etiology involves an interplay between hormonal, genetic and environmental factors. Viral infections, particularly Parvovirus B19 (B19V), are recognized as potential contributors to autoimmune pathogenesis and can induce transi...
Objectives: Autoimmune Encephalitis (AE) is an immune-mediated inflammatory disorder of the central nervous system with heterogeneous clinical manifestations and variable outcomes. The prognostic significance of antibody status (seropositive vs. seronegative) remains incompletely understood, particularly in Iranian pop...
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