NF-κB/NLRP3 inflammasome is associated with formaldehyde-induced reproductive and metabolic dysfunction: protective role of quercetin in rats

Organophosphate Pesticides Promote Cardiovascular Toxicity via NF-κB/NLRP3 Inflammasome Activation and Endothelial Dysfunction: Integrated In Vivo and In Vitro Evidence.

Cardiovascular diseases are increasingly linked to environmental toxicants, including widely used organophosphate pesticides. This study investigates the cardiotoxic potential of chlorpyrifos (CPF) and dimethoate (DM) using complementary in vivo and in vitro models. Female Wistar rats were orally exposed to CPF, DM and...

Nasal exposure to PM2.5 induces testicular injury and activation of pyroptosis-related signaling in rats: Inhibitor intervention and public transcriptomic analysis

Exposure to PM2.5 significantly elevated the levels of several testicular proteins, including NLRP3, ASC, cleaved caspase-1, cleaved caspase-1, cleaved caspase-3, GSDMD-N, total caspase-1, and full-length GSDMD, whereas cleaved caspase-3 did not differ significantly.

Metabolic Syndrome-Associated Pulmonary Lipid and Iron Accumulation and Alterations in TLR4/NF-κB Signaling and Ferroptosis-Regulatory Proteins Are Attenuated by Resveratrol Plus Quercetin in Rats

Metabolic syndrome (MetS) is associated with ectopic fat deposition, chronic systemic inflammation, oxidative stress, and increased susceptibility to organ dysfunction. While its cardiovascular consequences have been extensively studied, pulmonary al-terations remain less well characterized, particularly with respect t...

Neuroprotective effects of dapansutrile in rotenone-induced parkinsonism: targeting NLRP3/caspase-1, NF-κB, Nrf2/HO-1, and PINK1/Parkin pathways.

Chrysin-loaded casein nanoparticles protect against chlorfenapyr-induced renal injury through modulation of Nrf2/HO-1, NF-κB, and mitochondrial bioenergetics.

BACKGROUND Chlorfenapyr (CFP) is a pesticide that induces nephrotoxicity through oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Casein nanoparticles may enhance the therapeutic efficacy of chrysin (CY). OBJECTIVE This study evaluated the protective effects of free CY and chrysin-loaded case...

Quercetin alleviates splenic oxidative stress and inflammatory damage induced by long-term exposure to a mixture of phthalates in rats.

The results indicated that long-term MPEs exposure induced splenic inflammatory damage in rats, and Que exerted a significant alleviative effect likely through its antioxidant capacity.