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Review Open access Sep 2026

Cancer-associated synonymous mutations target mRNA structures and protein activity.

The role of adaptive mRNA structures in regulating gene expression in mammalian cells remains poorly understood. Synonymous mutations have been linked to a range of diseases, including cancer, yet their impact on cell biology remains largely unexplored. This opinion focuses on how cancer-associated synonymous mutations...

Robin Fåhraeus · 0 citations
Open access Aug 2026

Oncogenes have the most distinct codon biases in the genome and codon signatures that oppose tumor suppressor genes

Oncogenes and tumor-suppressor genes play opposing roles in cancer biology to promote and restrict growth, respectively. Codon usage patterns interface with tRNA modifications to control translation, leading to gene-specific codon signatures with regulatory potential. As such, codon-biased translational regulation has...

Chetna Mathur, Evan T. Davis, Dylan J. Ehrbar et al. · 0 citations
Open access Oct 2026

A ribosomal pseudouridine drives an oncogenic translation program

Dynamic ribosome heterogeneity has emerged as a potential layer of translational regulation, but whether variation in ribosomal RNA (rRNA) modification stoichiometry can selectively control the translation of mRNAs with shared encoded features remains unclear. Here we show that SNORA81-guided pseudouridylation at U4636...

Laurence Faucher-Giguère, Andrea Rivera-Pizana, Baudouin Seguineau de Préval et al. · 0 citations
Open access Sep 2026

Codon Usage Bias Analysis in Oral Cancer: Comprehensive Molecular and Evolutionary Insights.

BACKGROUND Oral squamous cell carcinoma (OSCC) is represented as a major global health concern with few treatment options. Codon usage bias (CUB) is a non-random selection of synonymous codons. It offers information on gene expression patterns and molecular evolution. METHODS This study examined CUB patterns in 1328...

Manal Abouelwafa, John J. Georrge, Supriyo Chakraborty · 0 citations
Aug 2026

Age-Opposed Rewiring of Upstream Translation-Initiation Pattern Across Different Types of Human Cancers.

The 5' mRNA leader regulates translation through its length and upstream open reading frames (uORFs), but its systematic remodeling in cancer remains unclear. We analyzed isoform-weighted 5' leader features across The Cancer Genome Atlas, the Genotype-Tissue Expression transcriptomes and the Clinical Proteomic Tumor An...

Ayon Pal, Ranav Pal, Vivek Roy et al. · 0 citations
Aug 2026

Oncogenic KRAS Rewires mRNA Stability and Translation through AGO2-Mediated Disruption of the miRNA pathway.

KRAS mutations occur in over 90% of pancreatic ductal adenocarcinomas (PDACs). Despite recent advances in targeting oncogenic KRAS, tumors eventually acquire resistance. A more comprehensive understanding of the mechanisms connecting KRAS signaling to tumor progression could facilitate the development of effective ther...

Z. Yang, Angelina S. Bortoletto, Mara G. Cardenas et al. · 0 citations

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