Overall, curcumin appears to be a promising adjunctive candidate for limiting secondary injury after SCI, but further mechanistic clarification and improved delivery strategies will be required to enhance translational relevance and support future clinical application.
Spinal cord injury (SCI) triggers a complex and evolving cascade of pathological events in which neuroinflammation and microenvironmental imbalance critically constrain repair. Among the cellular mediators, microglia exhibit remarkable functional plasticity, transitioning across diverse states that can either support t...
Zi-Yue Ma, Zi-Cheng Lu, Zi-Peng Zhou et al.· International Journal of Mol...· 0 citations
Preclinical and clinical evidence regarding caspase-1 and inflammasome-associated proteins across cerebrospinal fluid, serum, plasma, and other biofluids are summarized, emphasizing SCI and translational neuroinflammation.
Adonicah Y. Cummings, Adham M. Khalafallah, Bhavjeet S. Sanghera et al.· International Journal of Mol...· 0 citations
An integrated viewpoint for TMP in SCI treatment, a paradigm for understanding multi-target natural products, and a theoretical foundation for shifting from antioxidant to pro-regenerative strategies are provided.
The findings of this study provide a theoretical foundation and experimental basis for the clinical application of TAM in SCI treatment research and provide novel strategies for pharmacological intervention in secondary injuries associated with SCI.
Xiang-Zi Wang, Xiao-Quan Liang, Yu-Qi Lin et al.· Journal of Neuroimmune Pharm...· 0 citations
BACKGROUND
Hypoxic-Ischemic Encephalopathy (HIE) is a severe neonatal neurological disorder, in which oxidative stress serves as a central mediator of brain injury. Paeonol (Pae), a phenolic compound with established anti-inflammatory and antioxidant properties, remains underexplored as a therapeutic strategy for HIE....
Ding-Wang Hu, Jiang-Han Li, Ling-Bin Ye et al.· European Journal of Pharmaco...· 0 citations
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